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Introduction
SV388 is a permanent cell line derived from the malignantly transformed lymphoid tissue of a chicken. It is notable for its use in various biomedical research applications, particularly in the study of cancer and viral infections. Established in the 1970s, SV388 cells have since become a vital tool for researchers investigating tumor biology, viral oncology, and immune responses in avian systems.
Origin and Characteristics
SV388 cells were initially isolated from a specific strain of chicken fibroblasts transfected with the Rous sarcoma virus (RSV). This transformation was characterized by the presence of oncogenes and alteration of normal cellular mechanisms, leading to uncontrolled growth and url immortalization. One of the distinctive features of SV388 is its ability to proliferate indefinitely in culture, making it a reliable source of live cells for experiments.
SV388 is a permanent cell line derived from the malignantly transformed lymphoid tissue of a chicken. It is notable for its use in various biomedical research applications, particularly in the study of cancer and viral infections. Established in the 1970s, SV388 cells have since become a vital tool for researchers investigating tumor biology, viral oncology, and immune responses in avian systems.
Origin and Characteristics
SV388 cells were initially isolated from a specific strain of chicken fibroblasts transfected with the Rous sarcoma virus (RSV). This transformation was characterized by the presence of oncogenes and alteration of normal cellular mechanisms, leading to uncontrolled growth and url immortalization. One of the distinctive features of SV388 is its ability to proliferate indefinitely in culture, making it a reliable source of live cells for experiments.
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